1850s, CO2 Production, Oxygen Consumption Respiration Apparatus, Regnault and Reiset, 1850 November 29, 2014 Richard Johnston Leave a comment From Lehrbuch der Intoxikationen, Volume 1, by Rudolf Kobert, page 210. Published by F. Enke, 1902. Developed by Regnault and Reiset and originally used in 1850. Likely the first closed circuit system for measuring oxygen uptake and CO2 production.