1860s, CO2 Production Respiration apparatus, Pettenkofer, 1860’s November 29, 2014 Richard Johnston Leave a comment From Lehrbuch der Intoxikationen, Volume 1, by Rudolf Kobert, page 210. Published by F. Enke, 1902. A man-sized room used to measure CO2 production by Max von Pettenkofer in the 1860’s.